Shun-Fa Yang Selected Research

Gelatinases

10/2009	Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C.
4/2008	Effects of different molecular weight hyaluronan products on the expression of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis.
3/2008	Up-regulation of gelatinases and tissue type plasminogen activator by root canal sealers in human osteoblastic cells.
1/2008	Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans.
1/2008	Naproxen, meloxicam and methylprednisolone inhibit urokinase plasminogen activator and inhibitor and gelatinases expression during the early stage of osteoarthritis.
4/2007	Upregulation of urokinase-type plasminogen activator and inhibitor and gelatinase expression via 3 mitogen-activated protein kinases and PI3K pathways during the early development of osteoarthritis.
10/2006	Glucosamine sulfate suppresses the expressions of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis.
6/2006	Clinical correlation with the PA/plasmin system in septic arthritis of the knee.
10/2004	Clinical significance of gelatinases in septic arthritis of native and replaced knees.
6/2004	Examination of the signal transduction pathways leading to activation of gelatinolytic activity by interleukin-1alpha and Porphyromonas gingivalis in human osteosarcoma cells.

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Shun-Fa Yang Research Topics

Disease

246	Neoplasms (Cancer) 06/2022 - 01/2003
92	Neoplasm Metastasis (Metastasis) 06/2022 - 07/2004
79	Mouth Neoplasms (Oral Cancer) 01/2022 - 06/2003
53	Hepatocellular Carcinoma (Hepatoma) 01/2022 - 09/2003
41	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/2022 - 07/2007
39	Carcinogenesis 01/2022 - 10/2007
34	Inflammation (Inflammations) 03/2022 - 06/2002
33	Squamous Cell Carcinoma of Head and Neck 01/2022 - 06/2003
23	Osteosarcoma (Osteogenic Sarcoma) 06/2022 - 06/2004
23	Pneumonia (Pneumonitis) 01/2021 - 02/2005
20	Lymphatic Metastasis 01/2022 - 03/2008
20	Carcinoma (Carcinomatosis) 01/2021 - 04/2005
19	Lung Neoplasms (Lung Cancer) 12/2021 - 07/2004
18	Adenocarcinoma of Lung 01/2022 - 05/2012
15	Pelvic Inflammatory Disease (Pelvic Inflammatory Diseases) 01/2015 - 01/2008
14	Prostatic Neoplasms (Prostate Cancer) 04/2022 - 09/2013
14	Infections 01/2022 - 06/2006
11	Nasopharyngeal Carcinoma 05/2022 - 03/2010
10	Disease Progression 10/2020 - 03/2003
10	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2020 - 10/2013
9	Hypertension (High Blood Pressure) 06/2022 - 03/2013
9	Diabetes Mellitus 01/2022 - 04/2008
9	Osteoarthritis 01/2022 - 01/2004
9	Hypoxia (Hypoxemia) 03/2021 - 05/2012
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2021 - 04/2005
8	Anorexia 07/2011 - 04/2005
7	Fibrosis (Cirrhosis) 03/2022 - 03/2009
7	Renal Cell Carcinoma (Grawitz Tumor) 10/2020 - 10/2011
7	Leukemia 12/2019 - 06/2005
6	Breast Neoplasms (Breast Cancer) 10/2021 - 09/2006
6	Cardiovascular Diseases (Cardiovascular Disease) 08/2021 - 10/2009
6	Atherosclerosis 01/2019 - 07/2002
6	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2018 - 10/2007
6	Oral Submucous Fibrosis 09/2014 - 02/2002
5	Coronary Artery Disease (Coronary Atherosclerosis) 01/2020 - 03/2013
5	Obesity 01/2018 - 09/2010

Drug/Important Bio-Agent (IBA)

50	Proteins (Proteins, Gene)FDA Link 06/2022 - 06/2002
38	Matrix Metalloproteinases (MMPs)IBA 11/2020 - 06/2002
37	Matrix Metalloproteinase 2 (Gelatinase A)IBA 10/2021 - 02/2002
32	Messenger RNA (mRNA)IBA 11/2021 - 09/2003
29	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 09/2021 - 07/2004
28	Biomarkers (Surrogate Marker)IBA 11/2019 - 01/2009
25	MelatoninIBA 04/2022 - 03/2015
23	Matrix Metalloproteinase 9 (Gelatinase B)IBA 11/2020 - 07/2002
21	Plasminogen Activators (Plasminogen Activator)IBA 09/2021 - 07/2004
19	Environmental CarcinogensIBA 01/2020 - 03/2011
17	Pharmaceutical PreparationsIBA 06/2022 - 01/2007
15	CytokinesIBA 01/2022 - 06/2002
15	Long Noncoding RNAIBA 01/2022 - 01/2019
14	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 02/2005
14	Peptide Hydrolases (Proteases)FDA Link 09/2020 - 03/2008
14	FlavonoidsIBA 01/2020 - 01/2007
12	CaspasesIBA 06/2022 - 12/2013
12	Carbonic Anhydrase IXIBA 01/2022 - 01/2012
12	GelatinIBA 10/2019 - 06/2003
12	GelatinasesIBA 10/2009 - 06/2003
11	AntioxidantsIBA 12/2021 - 10/2013
11	p38 Mitogen-Activated Protein KinasesIBA 11/2021 - 10/2007
10	Biological ProductsIBA 05/2022 - 06/2009
10	ErbB Receptors (EGF Receptor)IBA 12/2021 - 01/2016
9	Small Interfering RNA (siRNA)IBA 02/2022 - 11/2011
9	Lipocalin-2IBA 06/2021 - 05/2011
9	A-factor (Streptomyces)IBA 05/2017 - 10/2009
8	CurcuminIBA 06/2022 - 03/2020
8	Cadherins (E-Cadherin)IBA 04/2022 - 09/2011
8	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2022 - 05/2007
8	Mitogen-Activated Protein KinasesIBA 07/2019 - 04/2007
7	Tissue Inhibitor of Metalloproteinase-3IBA 01/2022 - 09/2014
7	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 10/2004
7	HMGB1 Protein (HMG1)IBA 10/2020 - 04/2015
7	pterostilbeneIBA 01/2019 - 01/2014
7	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 12/2016 - 09/2010
7	Plasminogen Activator Inhibitor 1IBA 01/2015 - 06/2003
7	Tissue Inhibitor of Metalloproteinase-2IBA 09/2013 - 07/2002
7	Fibrinolysin FDA Link 01/2011 - 05/2003
6	Caspase 3 (Caspase-3)IBA 06/2022 - 02/2012
6	Antineoplastic Agents (Antineoplastics)IBA 01/2022 - 05/2016
6	JNK Mitogen-Activated Protein KinasesIBA 09/2021 - 04/2007
6	Type 4 Fibroblast Growth Factor ReceptorIBA 05/2021 - 01/2015
6	PTX3 proteinIBA 01/2021 - 10/2011
6	EnzymesIBA 01/2020 - 03/2003
6	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 05/2019 - 06/2010
6	Urokinase Plasminogen Activator ReceptorsIBA 01/2019 - 02/2006
6	MicroRNAs (MicroRNA)IBA 03/2018 - 01/2012
6	Carbonic Anhydrases (Carbonic Anhydrase)IBA 09/2017 - 09/2003
6	Glutathione Transferase (Glutathione S-Transferase)IBA 11/2011 - 04/2005
5	CarcinogensIBA 01/2022 - 12/2012
5	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 01/2014
5	InterleukinsIBA 01/2022 - 09/2005
5	WW Domain-Containing OxidoreductaseIBA 12/2021 - 10/2016
5	Metformin (Glucophage)FDA LinkGeneric 09/2021 - 12/2014
5	Aurora Kinase AIBA 01/2021 - 01/2017
5	Metalloproteases (Metalloproteinases)IBA 09/2020 - 10/2009
5	cathepsin SIBA 01/2020 - 01/2017
5	LigandsIBA 01/2020 - 10/2010
5	tricetinIBA 01/2020 - 01/2015
5	licochalcone AIBA 11/2019 - 01/2014

Therapy/Procedure

31	Therapeutics 04/2022 - 06/2004
17	Drug Therapy (Chemotherapy) 06/2022 - 01/2014
5	Radiotherapy 12/2021 - 01/2015